Newbie Question about OneDrive and Cryptomator

[Michael]

If you have anywhere else enough free space, you can create your vault there and configure the OneDrive App to use this path as sync folder.
If not I do not see a way to do this with Cryptomator desktop. But you can give cyberduck a try if you want to create/access a vault directly online in your OneDrive storage (then of course without the sync of the OneDrive app).

How do I use Cryptomator without local sync?

You can use cyberduck.io to access cryptomator vaults directly on your cloud drive. Then you don’t need to sync the encrypted files with your local storage.