Can't encrypt large file to Mac OS Extended and ExFat format external HDD

I was trying to encrypt a 33GB file to 2 external hard disks (Mac OS Extended and ExFat format) through Cryptomator but failed. There was a warning “The operation can’t be completed because the disk is full” during the process.

It seems doesn’t related to the format of hard disk because the situation happened on external hard disk in both Mac OS Extended and ExFat format. What should I do to fix the problem? Thank you.