Access denied on my 2 of my vaults

I have over 450 photos and videos on 2 vaults, running Win 10, I can open both vaults, see every file, cannot copy, cannot erase even using unlocker, and cannot move. can not see or watch videos. I checked it one way. It says I/O error, and unlocker program says access denied. I have tried copying to different drives, renaming drives, etc, but I give up, and lost cause, Do any new ideas