Mac Photos and Music DB into vault

Hello,

My idea is to create a Cryptomator vault to sync with a cloud (OneDrive, Dropbox,…) and put my photo database from Apple Photo and also my music database from Apple Music into this vault.

As these are big databases (several 100 GB) and I’m also not sure about the disc formatting (I understood with MacFuse this is not the origin Mac data file formatting) I like to ask you first: Should that work without issues or could problems arise?

Thanks and bye
Philipp