Huge Cryptomator fans here. But:
When we started to use the combination of Goole Drive and Cryptomator on a larger scale in our team, i.e. 5 Vaults shared to different people, each containing 500 files and syncing / editing around 3 files per day, we ran into the issue that Drive stopped to download files at all (enrcypted and not encrypted files). Uploading of edited files still works fine, however.
We recently migrated to Tresorit. We will see how it will work.